EUROPE Regulatory data protection expired on 4 January 2026 and compound patent will expire on 20 March 2026
Lack of visible peeling does not indicate lack of efficacy
The PTSD Checklist (PCL): Reliability, Validity, and Diagnostic Utility
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Histologic Features Hyperpigmentation of the basal keratinocytes with prominence, but not increase of mostly dendritic melanocytes Subjacent mucosal melanophages and fibrosis Absence of melanocytic nests, cytologic atypia, pagetoid scatter Differential Diagnosis Post-inflammatory hyperpigmentation Lentiginous junctional melanocytic nevus Melanoma in situ Takeaway Essentials Clinical Relevant Pearls Can have variegated color and very irregular contours raising concern for melanoma Pathology Interpretation Pearls Hyperpigmentation of the basal keratinocytes can be subtle Comparing the hyperpigmented areas with the adjacent normal, non-hyperpigmented epidermis may provide the only clue Immunohistochemical/Molecular Findings In difficult cases immunohistochemistry for Mart-1 and/or MiTF-1 can be helpful in excluding melanoma in situ Post-inflammatory Hyperpigmentation Clinical Features Post-inflammatory hyperpigmentation, as the name implies, is pigmentation that occurs in the setting of a genital eruption that has an inflammatory component, particularly one that is directed at the epithelium [7, 35]
