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Retatrutide is an investigational triple GIP/GLP-1/glucagon receptor agonist and currently provides the strongest clinical support for the glucagon paradox

Importantly, this is the first biologic to show a truly meaningful level of clinical effect in patients, which could expand the number of patients we can treat with this immune disorder," said Jonathan Silverberg, Dermatologist at The George Washington University School of Medicine and Health Sciences, in the press release

This is not necessary for preparations such as once-weekly exenatide because the protracted action is the result of slow absorption, while the elimination of circulating exenatide follows the same kinetics as known for un-retarded (b.i.d.) exenatide (Table 1)

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