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The study did, however, also highlighted several negative side effects, including constipation (118 occurrences), diarrhea (100 events), and abdominal pain (41 events per 1,000) ( Abdominal pain, nausea, vomiting, and diarrhea are among the gastrointestinal adverse effects linked to GLP-1 RAs
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Loraine Baraki the timing hypothesis & the brain 1:16:15 What actually kills postmenopausal women 1:17:31 Fitness: the biggest mortality lever 1:20:21 Strength, power & grip 1:25:15 Clinic: where to start when you're overwhelmed 1:30:41 The detraining problem 1:32:38 Trained vs untrained: what's recoverable 1:34:53 The actual plan 1:39:48 Takeaways Resources: Subscribe to BBM Plus for the full unabridged Direct Line: Barbell Medicine coaching and templates: Signal book pre-order: Body composition & metabolism Greendale et al., SWAN body composition, JCI Insight 2019: Lovejoy et al., visceral fat across the transition, Int J Obes 2008: Pontzer et al., daily energy expenditure across life, Science 2021: Karppinen et al., metabolism in midlife women, Eur J Prev Cardiol 2023: Cardiometabolic Matthews et al., lipid changes & the menopause transition, JACC 2009: Janssen et al., menopause & metabolic syndrome (SWAN), Arch Intern Med 2008: El Khoudary et al., AHA Scientific Statement on midlife women, Circulation 2020: Bone Greendale et al., SWAN bone loss across the FMP, JBMR 2012: Siris et al., undiagnosed low BMD & fractures (NORA), JAMA 2001: Watson et al., LIFTMOR, JBMR 2018: Kemmler et al., EFOPS 16-year, Menopause 2017: Kistler-Fischbacher et al., MEDEX-OP, JBMR 2021: Sherrington et al., exercise for preventing falls, Cochrane 2019: ACSM Position Stand: Osteoporosis and Exercise, Med Sci Sports Exerc 1995;27(4):ivii (no DOI) Cognition & mood Greendale et al., SWAN cognition, Neurology 2009: Kravitz et al., sleep in midlife women, Obstet Gynecol Clin North Am 2018: Cohen et al., Harvard Study of Moods and Cycles, Arch Gen Psychiatry 2006: Bromberger & Kravitz, mood and menopause (SWAN), Obstet Gynecol Clin North Am 2011: Livingston et al., Lancet Commission on dementia 2024: Shumaker et al., WHIMS (estrogen+progestin & dementia), JAMA 2003: Espeland et al., WHIMS (estrogen-alone & cognition), JAMA 2004: Gleason et al., KEEPS-Cog, PLoS Med 2015: Henderson et al., ELITE (timing hypothesis & cognition), Neurology 2016: USPSTF, hormone therapy for primary prevention, JAMA 2022: Fitness & mortality Mandsager et al., cardiorespiratory fitness & mortality, JAMA Netw Open 2018: Kodama et al., fitness & mortality meta-analysis, JAMA 2009: Sui et al., fitness & adiposity in older adults, JAMA 2007: Momma et al., muscle-strengthening activity & mortality, Br J Sports Med 2022: Arajo et al., muscle power vs strength & mortality (CLINIMEX), Mayo Clin Proc 2025: Leong et al., grip strength & mortality (PURE), Lancet 2015: Detraining & trained-vs-untrained Troiano et al., accelerometer-measured activity, Med Sci Sports Exerc 2008: Fleg et al., aerobic-capacity decline (BLSA), Circulation 2005: Ratley et al
