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At the somatic mutation stage, Keap1 is inactivated, which enhances Nrf2 expression in the nucleus and induces cytoprotective genes such as heme oxygenase-1 [HO-1 (HMOX1)] and NAD(P)H:quinone oxidoreductase 1 (NQO1) (Sporn and Liby, 2012)

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The review aimed to address two major clinical domains: (1) the emerging therapeutic potential of GLP-1 RAs in dermatology and aesthetic medicine

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