Cordoba-Chacon, J
ROS production can occur at several intracellular sites but, for most cells, takes place in the mitochondria and the mitochondrial electron transport chain is the main cellular process of ROS generation in physiological circumstances (14)
However, leptin serum levels are chronically increased in individuals with obesity, resulting in leptin resistance similar to insulin resistance also observed in obesity, which can result in a loss of its antisteatotic effects [32]
Martinez 6,7 , Maria Galn 8,9* , Affiliation: 1 Group of Endocrinology, Diabetes and Nutrition, Institut de Recerca Sant Pau, 08041 Barcelona, Spain 2 CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain Email: [email protected] ORCID: Josep Julve 1,2* Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a complex chronic metabolic dysfunction of the liver influenced by both genetic and non-genetic factors [1]
M., Cho, W
Edited by Guo-Qiang Chen Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made
