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213 Red yeast rice extracts have also been shown to be well tolerated and effective in lowering LDL in patients with statin intolerance 214,215 and safe and effective in LDL-lowering even in younger individuals

For details, see the Fermented Dairy Foods section of the Probiotic Supplements Review

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There was a tendency toward higher t 1/2 with increasing hepatic impairment, but applying the same rationale as stated above for participants with renal impairment, this was not considered clinically relevant