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Sahasrabuddhe VV, Gunja MZ, Graubard BI, Trabert B, Schwartz LM, Park Y, Hollenbeck AR, Freedman ND, McGlynn KA (2012) Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma

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Species differences in metabolism, receptor expression, and pharmacokinetics mean that effective doses in rats do not predict safe or effective doses in humans

This provides a robust rationale for its application in neurodegenerative diseases and enriches the contemporary biological understanding of acupuncture-mediated neuroprotection (69, 70)

Figure 3: Homocysteine (Hcy) follows two pathways in cells: one turns it into methionine, and the other into cystathionine