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It is oil-soluble which means it is more likely to penetrate the skin compared to the pure form of vitamin C (which is water-soluble), but it is less bio-available and is way less effective in stimulating collagen and reducing wrinkles compared to the pure form of vitamin C (L-ascorbic acid) and its other derivatives (for example, magnesium ascorbyl phosphate)

Conversely, mice that had been genetically engineered to lack adiponectin failed to respond to the once-weekly treatment with prednisone

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It is also worth noting that, in clinical practice, histamine intolerance and MCAS are frequently seen alongside other connective tissue conditions, including hypermobile Ehlers-Danlos syndrome (hEDS) and Postural Orthostatic Tachycardia Syndrome (POTS) a triad that overlaps significantly with lipoedema and warrants consideration in women presenting with complex, multisystem symptoms