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doi: 10.1016/j.redox.2023.102752

Redox biology , 11 , 701-707

A Physiological Toxicokinetic Model for 1,3-Butadiene in Rodents and Man: Blood Concentrations of 1,3-Butadiene, Its Metabolically Formed Epoxides, and of Haemoglobin Adducts--Relevance of Glutathione Depletion. Toxicology 113 (1-3): 300305

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Critically, these effects were achieved without food intake suppression, distinguishing MOTS-c from GLP-1 receptor agonists whose primary mechanism involves appetite reduction

Shorter transit = less cumulative temperature exposure = better vial condition on arrival