Plans should take into account the likelihood of approval if non-formulary, considering the limited alternative options for this indication and mechanism of action
In particular, glutathione (GSH) depletion is a common feature of apoptotic cell death triggered by a wide variety of stimuli including activation of death receptors, stress, environmental agents, and cytotoxic drugs
10.1186/1476-4598-12-72 51 IrelandL.SantosA.AhmedM
Conversely, CPA/EE showed a stronger effect to reduce androgens levels (99)
Researchers sought to investigate the efficacy of L-citrulline and/or GSH on markers indicative of NO synthesis and found that daily oral supplementation with 200mg of Setria Glutathione and 2g of L-citrulline enhanced levels of nitric oxide, concluding that Setria Glutathione not only enhanced blood levels of NO, but may sustain levels by preventing its oxidative reaction when ingested in combination with L-citrulline
10.1146/annurev.arplant.54.031902.134934 24 DietzK