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The AGE-RAGE system may be responsible for the failure of ovulation characteristic of PCOS: in a model of human cell lines of granulosa, observed that the AGE interfere in vitro with the action of LH leading to altered follicular development and therefore the dysfunction ovulatory associated with PCOS [65]

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Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn

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To prevent these side effects, the dosage is escalated slowly according to your tolerance