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During pregnancy, a womans body contains HCG in amounts as high as 300,000 IU on a daily basis

thus, B12 deficiency causes a functional folate deficiency known as the folate trap (Bender 2003)

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Your healthcare provider may increase the dose to 1.5 mg weekly after at least four weeks if additional glycaemic control is needed, with further stepwise titration possible to 3.0 mg and then to a maximum of 4.5 mg weekly, with at least 4 weeks at each dose level