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Key points Multiple pathways can cause cartilage regeneration to fail following injury, thereby leading to a cascade of events that ultimately results in a degenerative disease state

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

These rates were calculated from the slope of the lines drawn through the graph from 0 to 10 h (fast-release, 4.3% of DNAzymes released/hour) and from 10 to 48 h (slow release, 0.2% of DNAzymes released/hour)

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