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Gastroenterology 98 , 406413 (1990)

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However, very high intakes of PEITC or BITC (25 to 250 times higher than average human dietary isothiocyanate intakes) have been found to promote bladder cancer in rats when given after cancer initiation by a chemical carcinogen (70)

Ferroptosis also generates reactive oxygen species (ROS) by releasing Mn2+, serving as a supplementary mechanism for Ferroptosis induced by lipid hydrogen peroxide (120)