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Compounded versions may: Use alternative salt forms Have variable concentrations Differ in stability or formulation Not undergo the same clinical trial process Compounding has a role in medicine when a medication is unavailable or a patient requires a customized dose

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Figure 11 shows the EPR spectrum of the ascorbyl radical (Asc ) in the ischemic rat brain homogenates recorded 5 months after 3-vessel occlusion (Kasparova et al

doi:10.1111/j.1365-2230.2006.02128.x

In consequence, with the thrombocytopenia and haemorrhage, the expected lack of NO-suppression of platelet aggregation [33], the acceleration and amplification of the induced pattern of platelet activation resulting in platelet exhaustion [9] (L-NAME), grossly correspond to the suggested inhibition of platelet aggregation, by direct action on an intraplatelet constitutive calcium-dependent NOS [3335] (L-arginine)