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J Biol Chem 282:68236832 Tao R, Coleman MC, Pennington JD, Ozden O, Park S-H, Jiang H, Kim H-S, Flynn CR, Hill S, McDonald WH (2010) Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress

The data of gene expression profiling have been uploaded to the NCBI Gene Expression Omnibus under accession number GSE152537

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Since the mevalonate pathway is closely related to ferroptosis through regulating expression of GPX4, production of squalene and coenzyme Q, and sterols are known to exert intricate feed-back regulations on this pathway to restrict cholesterol overproduction, we hypothesized that cholesterol and its metabolites would modulate cell sensitivity to ferroptosis

10.1038/ijos.2012.40 60 GurtnerG

Oleuropein as a novel anti-diabetic nutraceutical