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It usually starts in the rectum and can spread upward in a continuous pattern

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Minor bruising or tenderness at the site is possible but fades quickly

This disorder reduces serum unsaturated fatty acid content, especially eicosapentaenoic acid and docosahexaenoic acid, while branched-chain fatty acids accumulate, subsequently leading to significantly elevated liver injury indicators

Animal Toxicology Limitations Some animal experiments did not report obvious toxicity or increased total tumour incidence

The primary outcome measure for most studies was some form of patient-rated symptom scales, including the Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), and a Visual Analog Scale (VAS) as available