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FOXO4 plays a key role in regulating cell cycle control, stress resistance, and apoptosis, while p53 is a central regulator of DNA damage response a

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Using fibroblasts induced to senesce by ionizing radiation, we further observed that p53 is phosphorylated on Serine 46 and that removing FOXO4 could trigger a clean cell death response, known as apoptosis (de Keizer&Campisi, Cancer Res (2011) 71 (18_Supplement): C35.)

The circulatory system as a whole is responsible for transporting the most important and essential substances in our body, including oxygen and nutrients