If a patient takes a second drug that is a potent inhibitor of the relevant metabolic enzyme, it might reduce the liver's metabolic capacity and decrease the extraction ratio by a seemingly modest amount, for example, to E = 0.7
Clemente-Surez VJ, Beltrn-Velasco AI, Redondo-Flrez L, Martn-Rodrguez A, Tornero-Aguilera JF
Functional contribution of the spastic paraplegia-related triglyceride hydrolase DDHD2 to the formation and content of lipid droplets
Common Mistakes We've Seen (And How You Can Avoid Them) Over the years, our team has consulted with countless researchers, and we've seen a few common, preventable errors pop up again and again
Lancet 392 , 15191529 (2018)
Its mechanism is competitive inhibition within the NNMT catalytic pocket, blocking the methyl transfer from SAM to nicotinamide