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The hypothalamic-pituitary-gonadal (HPG) axis is crucial for semen production and maintenance of sexual function in men (167) and thus reduces the pulsatile secretion of the major regulators of spermatogenesis: FSH, LH, and testosterone, affecting semen parameters (168)
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For instance, in models simulating certain pathological conditions, GHK was observed to downregulate genes associated with inflammation and tissue destruction while upregulating genes involved in antioxidant defense and tissue remodeling