NIX can directly bind to LC3 in the BH3 domain, recruiting phagosomes (precursors of autophagosomes) to mitochondria and acting as autophagy receptors, mediating mitochondrial clearance after mitochondrial damage and red blood cell differentiation [71]
[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Valenti D., de Bari L., De Filippis B., Henrion-Caude A., Vacca R.A
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Key Industry Developments In August 2025 , research from Rockefeller University identified mitochondrial glutathione as a critical metabolite enabling breast cancer metastasis, with elevated levels in metastatic cells facilitating survival in new tissues through signaling mechanisms rather than antioxidant activity
Endod Topics 6:2956