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A review in Drug Metabolism Reviews found that berberine undergoes extensive first-pass metabolism after oral administration, resulting in very low plasma exposure

Nat Neurosci 16:571579 Ilieva H, Polymenidou M, Cleveland DW (2009) Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

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Its ideal to start taking a daily prenatal three months before you start trying in order to build up enough nutrients in your system and to impact eggs, which take about 90 days to mature