Science 1948;107:396
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[44] demonstrated that acute administration of a MC4R agonist into the medial amygdala in the setting of restraint stress resulted in increased anxiety behavior in rats accompanied by increased c-Fos mRNA expression in medial amygdala MC4R neurons
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Additionally, a randomized trial showed a benefit in disease-free survival in breast cancer patients receiving presurgical peritumoral injection of lidocaine, which is also a VGSC inhibitor (331)
[9] Fakhary, M., Xia, F., Koroma, M., & Dennison, M