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As previously mentioned, results from a clinical proof-of-concept trial recently found that anti-IL-21 plus liraglutide was significantly better than placebo in preserving C-peptide secretion over a period of 54 weeks [61]

Acute renal effects of the GLP-1 receptor agonist exenatide in overweight type 2 diabetes patients: a randomised, double-blind, placebo-controlled trial

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57 The absolute or relative insufficiency of insulin secretion is a characteristic feature of all common forms of diabetes mellitus

Treatment should be discontinued if less than 5% weight loss is achieved after 12 weeks at the full dose