When your hormones are fluctuating, your body is more sensitive to environmental stressors
Epidemiological and clinical investigations have suggested that the consumption of coffee could reduce the risk of alcoholic liver cirrhosis (15), type-2 diabetes (16), NAFLD (17), and HCC (18, 19), and reduce the progression of NASH, the severity of fibrosis (20), and alanine aminotransferase (ALT) activity in patients with liver injury (21)
Furthermore, NaB-enhanced GLP-1R expression in HepG2 cells by inhibiting histone deacetylase-2 independent of GPR43/GPR109a
The risk of cardiovascular death for T2D patients with and without GLP-1 RA stratified by variables
However, their therapeutic utility has been limited by issues such as low solubility, short biological half-life, high lipophilicity, dose-dependent toxicity, and nonspecific accumulation in the body [333]
The author JR-K declared that they were an editorial board member of Frontiers at the time of submission