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In these systems, stimulusresponsive platforms, such as those responsive to pH [447], redox [448], and light [449] have been implemented for controlled drug release

One of the most effective strategies is the inclusion of specific nutrients such as amino acids, vitamins, minerals, lipids and fatty acids, as prebiotics, nucleotides, which play a crucial role in managing stress [29]

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Ipamorelins unique structure, incorporating synthetic amino acids including aminoisobutyric acid (Aib) at the N-terminus and D-isomers at positions 3 and 4, confers both metabolic stability and highly selective receptor activation

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The primary drug resistance mechanisms of HGSOC are illustrated in Figure 2