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SHK@HA-MPDA effectively inhibited cytoplasmic PKM2 tetramerization and attenuated its nuclear translocation, significantly reducing lactate and ATP production in CT26 cells

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Clinical trials of semaglutide showed striking results: over about 16 months, half of the participants lost 15% of their body weight, and nearly one-third lost 20% of their weight using the drug

Moreover, results from animal studies have consistently demonstrated the detrimental effects of oxidative stress on central nervous system 15,16