Correspondingly, combined treatment with sertraline, an inhibitor of serine/glycine conversion, and radiotherapy significantly impairs the proliferation, clonogenicity and stem cell self-renewal capacity of NSCLC cells, and also effectively suppresses tumor growth in in vivo experiments ( 4.1.2 Colorectal cancer Genes involved in the SSP are generally highly expressed in colorectal cancer and are correlated with unfavorable patient prognosis ( Meanwhile, activation of the Wnt pathway in turn promotes the transcription of SHMT2, forming a positive feedback loop of the SHMT2Wnt/-catenin axis that further strengthens the metabolic output of the SSP ( Clinical samples have confirmed that approximately 82% of OXPHOS-deficient colorectal cancer tissues harbor mtDNA mutations, and the SSP activity in these tumors is significantly higher than that in normal tissues ( The transcription factor FOXC1 has also been shown to reprogram serine metabolism under serine-deprived conditions to promote colorectal cancer proliferation and 5-fluorouracil resistance
These specific species-metabolite associations clearly differentiated NC-CKD, d-CKD, and H-CKD patients from healthy controls with an AUC value of 0.962, 0.913, and 0.901, respectively
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Moreover, lactate derived from glycolysis serves as a key immunosuppressive effector, dysregulating functions of T cells, macrophages, and other immune cells [19, 20]
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Nitrogen (N) was determined using Kjeldahl method ( 2.6 Quantification of lipid peroxidation, hydrogen peroxide and lipoxygenase activity Lipid peroxidation was assessed by measuring malondialdehyde (MDA) content, following 2 O 2 ) concentration was determined according to 2.7 Quantification of ascorbate-glutathione cycle components Plant tissue (0.5 g) was frozen in liquid nitrogen and homogenized in 5 mL of 10% TCA containing 1.5 mM EDTA
