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The Lancet 2026 For deeper curations and analysis on digital health, AI, and evidence-based decision-making, I share regular insights in my newsletter Evidence Decoded.Join here: This is becoming one of the most well-evidenced drug classes in modern medicine

Clinical Evidence on Weight Regain Rates and Timeline A landmark 68-week trial found that patients who stopped semaglutide after achieving significant weight loss regained an average of 2.3 pounds per month during the first 6 months off medication

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Regular exercise not only burns calories but also improves insulin sensitivity and overall metabolic health

3b and Supplementary Table 2)