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So the first honest distinction is structural: tesamorelin is a modified full-length analog engineered for resistance to degradation, whereas sermorelin is an unmodified short fragment that reproduces GHRH activity but not GHRH stability

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In the crystal structure of oxy-tyrosinase complexed with the caddie protein, the hydroxyl group is positioned near the two peroxide oxygens within a distance of 3.5 (S1B Fig)