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It underscores the limitations of single-targeted treatments and highlights the urgent need for multi-target approaches, search for clinical markers to enable early diagnosis, and robust clinical trial designs

Older adults or those with reduced physiological reserve may benefit from a more cautious escalation approach

compounding pharmacies and routes every protocol through a licensed clinician

[] Modification of Millards rotational flap is still widely used in spite of advantages conferred by the Fishers technique

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