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Arch Of Pharmacal Res (2020) 43:37184
(1) Benjamin Bourgeois and Tobias Madl (2018) Regulation of cellular senescence via the FOXO4p53 axis FEBS Letters, 2018 May 13, Volume 592 (Issue 12), Pages 20832097
The decline is normal, but its effects accumulate: less deep sleep triggers less overnight GH release, which further reduces muscle maintenance, which shifts body composition toward higher fat percentage, which further suppresses GH through somatostatin signaling
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