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Patients should discuss with their provider whether dual-agent therapy or single-agent GLP-1 best aligns with their clinical profile and goals

The barrier breakdown also allows the intestinal microbiota and its derivatives (e.g., lipopolysaccharides (LPS)) to penetrate the epithelial barrier, which triggers innate and adaptive immune signaling pathways 68

This state enhances their stability, allowing for longer storage at appropriate temperatures (typically refrigerated)

Doctors usually start with a low dose and increase it slowly to reduce side effects