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At a cellular level, IF stimulates autophagy, promoting the clearance of damaged proteins and organelles and reducing oxidative stress within the gastrointestinal tract [73]

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In acute lung injury (ALI) models, EVs engineered with a RAGE antagonist peptide and loaded with anti-miR-155 oligonucleotides efficiently inhibit pro-inflammatory signaling pathways and reduce cytokine levels, enabling precise modulation of pulmonary inflammation [212]

doi: 10.1016/j.ymthe.2022.03.015 54 HallZChiarugiDCharidemouELeslieJScottEPellegrinetLet al