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[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Wallace A.S., Chang A.R., Shin J.I., Reider J., Echouffo-Tcheugui J.B., Grams M.E., Selvin E

Sebum plays a vital role in keeping the skin hydrated and lubricated, as well as protecting it from external factors like bacteria and environmental pollutants

10.1002/iub.2008 55

Notably, Orforglipron (EC 50 1.2 nM), a pyrazolopyridine derivative that acts as a biased partial agonist and is administered orally once daily, has entered Phase III clinical trial (NCT3502970)