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In this case, an anti-PD-1 could be considered for the treatment of type 1 diabetes

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These orphan nuclear receptors regulate transcriptional programs involving mitochondrial respiration, oxidative phosphorylation, fatty-acid oxidation, skeletal-muscle oxidative capacity, and metabolic adaptation

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doi:10.3109/03602538308991399

The specificity of peptides can enhance the effectiveness of these combinations while potentially reducing overall toxicity