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A Shimadzu Prominence Ultra-Fast Liquid Chromatographer (LC) interfaced to a Thermo Scientific Q Exactive Mass Spectrometer (MS) with a Thermo Scientific heated electrospray ionization (HESI-II) probe was used for LCMS/MS

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No other single injectable compound does all three

Patients on tirzepatide lost an average of 20.2% of their body weight over 72 weeks Patients on semaglutide lost an average of 13.7% of their body weight over the same period 47% more tirzepatide patients achieved 25% or greater body weight loss compared to semaglutide Tirzepatide also produced greater reductions in waist circumference across all dose comparisons A 2024 meta-analysis published in JAMA Internal Medicine analyzing real-world data from over 140,000 patients confirmed the same pattern: tirzepatide produced an average of 4.23 kg more weight loss than semaglutide across all doses and durations studied

doi:10.1177/03635465251357593

However, the possibility of underdosing, contamination, or formulation errors exists in compounded products