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Specifically, the addition of cuprizone (bis-cyclohexanone oxalydihydrazone), to the diet process (66) produces a massive demyelination in different areas of the CNS and particularly in the corpus callosum (67-69)

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Ethics declarations Ethics approval and consent to participate All procedures were conducted in accordance with Chinese animal research laws and approved by the Experimental Animal Management Committee (EAMC) of Northwest A&F University (Protocol No

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