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There isn't one obesity The first thing to understand, Kushner says, is that obesity isn't a single condition

Research using MT-1 in cell systems expressing MC1R variants associated with red hair and fair skin has characterised reduced cAMP signalling responses, impaired MITF activation, and decreased melanogenesis , documenting the functional consequences of loss-of-function MC1R polymorphisms at the receptor signalling level and establishing the molecular basis for the reduced photoprotective melanogenesis capacity associated with these variants

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International Journal of Molecular Sciences, 21(5):1744.

Sazali, S., Badrin, S., Norhayati, M.N., Idris, N.S

Additionally, they may contain laxatives, diuretics and sometimes stimulants like high doses of caffeine