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Data availability Data generated and analyzed in this study are included in the paper and the Supporting Information (supplementary Figures 1-7 and legends), and are also available to interested person from the corresponding author upon reasonable request

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Methylcobalamin and adenosylcobalamin are native forms of B12, while hydroxycobalamin or cyanocobalamin are not

Cellular senescence research: As a telomerase activator, this compound is a primary research tool in studies of cellular senescence, replicative lifespan, and the biology of the Hayflick limit.

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