showed that under combined hypoxia and TGF-1 stimulation, paricalcitol inhibits Smad2 phosphorylation, regulates hypoxia-inducible factor-1 (HIF-1) signaling, and reduces oxidative stress, thereby blocking the transition of pericytes into myofibroblasts (38)
A multi-institutional study in Taiwan by Lin and colleagues found that GLP-1RA users were more likely than sodium-glucose cotransporter 2 inhibitors (SGLT-2I) users to develop PDR or require interventions for DR complications
Mounjaro can be administered with or without food, which provides flexibility
Increase Hydration to Support Bowel Movement Dehydration is the single most common cause of constipation on GLP-1 therapy
Dark Spots and Pigmentation Reduction: The active blend gently softens the appearance of marks, helping the skin look clearer and smoother
Zinc also supports the immune system directly by aiding in immune cell development and function