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doi: 10.1186/s12967-025-06635-8 50

Combination therapies: Orforglipron could be combined with other oral agents (e.g., oral GIP agonists, SGLT-2 inhibitors, phentermine) for enhanced efficacy, or formulated as a fixed-dose combination tablet

2,3Patients with LADA tend to meet the following criteria: Absence of obesity Over 30 years of age upon diagnosis Unable to manage diabetes with non-insulin medications or lifestyle/dietary modifications Management and Prevention of LADA Metformin and Thiazolidinediones Insulin sensitizers such as metformin and thiazolidinediones (e.g., pioglitazone, rosiglitazone) work to lower blood glucose levels by increasing muscle, fat, and liver sensitivity to insulin

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The price difference between the prescription drugs and the supplements has some people eager to try the alternative products

This can create dangerous gaps in care, especially for individuals managing type 2 diabetes