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Curr Opin Endocrinol Diabetes Obes (2013) 20:4418

doi: 10.1038/s41586-019-1865-0 98 PaikDYaoLZhangYBaeSDAgostinoGDZhangMet al

However, since the tubular reabsorption occurs via an active transporter, once the transporter is saturated by the high plasma L-carnitine concentrations achieved by intravenous administration, the circulating L-carnitine is rapidly excreted

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Thus, no beneficial effects with respect to an enhancement of serum GSH and TEAC levels or a decrease in serum MDA concentrations were demonstrated after coffee enema or orally consumed ready-to-drink coffee.