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Researchers exploring the peptide research landscape should interpret combination protocols as rational but unproven, guided by biological plausibility rather than definitive clinical evidence

2014 paper demonstrating Dihexa's synaptogenic effects through the HGF/c-Met system was retracted in April 2025 (PMID: 40312093)

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The mainstream copper-biology research community and the broader peptide research community have engaged with the GHK-Cu literature at various points, but the depth of independent characterization outside the Pickart-affiliated research has been variable

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