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2015 Jan;7(1):31-8

Importantly, preclinical studies showed that weight reduction occurred particularly in abdominal adipose tissue, the visceral fat depot most strongly associated with metabolic health risks

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NEJM 2011;365:15971604: 10.1056/NEJMoa1105816

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When you calculate cost per pound of fat lost, semaglutide may actually represent better value despite the higher sticker price, at least based on clinical trial data