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In neurodegenerative diseases, such as ALS, AD, and MS, the persistent strong proliferative response of microglia is a crucial part of these basic pathological processes [183]

As the loss of POLRMT results in severe mitochondrial dysfunction in cardiac muscle 70 , a similar mitochondrial dysfunction should occur in beta-cells with the loss or dysfunction of POLRMT, resulting in insulin resistance and diabetes mellitus

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Diabetes Care 48 , 13861394 (2025)