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357 IR in adipose tissue leads to high FFAs levels, 358 visceral fat accumulation that is associated with elevated levels of plasminogen activator inhibitor 1 (PAI-1) and BP, 359 and ectopic lipid and toxic lipid metabolite accumulation (lipotoxicity) in blood vessels that alters cellular signaling and cardiac structure, thereby contributing to the increased prevalence of cardiovascular diseases

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The sections were washed in a phosphate-buffered saline (PBS) buffer and incubated in a 3, 3-diaminobenzidine (DAB) solution for 3 min

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TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders