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While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

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Other circadian clock proteins, such as Rev-erb have also been implicated as a mediator of microglial activation and neuroinflammation, where the authors observed a time of day difference in microglial immunoreactivity in the hippocampus (Griffin et al., 2019)

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B12 is crucial for the production of red blood cells and the maintenance of healthy nerve cells

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