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Hofstetter CP, Schwarz EJ, Hess D, Widenfalk J, El Manira A, Prockop DJ, et al

If any of these considerations raise concerns, discuss them with the evaluating provider during your consultation before committing to treatment

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They also suggested that factors that alter the function of the blood-brain barrier (BBB), such as hypoxic or ischemic stroke, inflammation that causes endothelial upregulation of surface adhesion molecules, and disruption of the BBB barrier function by the cancer, may alter the penetration conditions and reduce the permeability of the drug through the BBB [24]

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