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Community sources describe starting conservatively at 0.25 mg 3x weekly (0.75 mg total weekly) for the first 2-4 weeks the dual GLP-1/GIP mechanism can cause more intense initial GI side effects than single-target agonists

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The unique mechanism of action not only aids in glycemic control but also promotes satiety, which can lead to reduced caloric intake and support weight loss efforts, a critical component for many individuals managing type 2 diabetes

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Alternatively, they may be deficient in B12 for other reasons